Swiss Chems BAM-15 is an important new addition to the world of research chemicals, specifically in the field of mitochondrial uncouplers. Scientists are very interested in this compound because it could be useful for studying metabolic diseases.
BAM-15 works by acting as a mitochondrial protonophore, which means it has the ability to transport protons across mitochondrial membranes. What sets BAM-15 apart from other uncouplers is its unique properties that allow it to do this without causing harm to the cells.
Potential Applications in Metabolic Disease Research
Researchers have been looking into how BAM-15 can be used to better understand metabolic diseases, and so far, the results have been promising. Here are some areas where studies suggest BAM-15 could play a role:
- Regulating energy expenditure
- Modulating mitochondrial efficiency
- Enhancing metabolic rate
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Importance of Mitochondrial Uncouplers in Research
Mitochondrial uncouplers like BAM-15 are valuable tools for scientists conducting research. They help researchers study how cells generate and use energy. Specifically, BAM-15's controlled uncoupling properties make it possible to investigate:
- Changes in metabolic pathways
- Patterns of energy expenditure
- Responses of cells to different conditions
With Swiss Chems' BAM-15, researchers now have access to a compound that can aid in these complex biological investigations. This could lead to a better understanding of metabolic disorders and potential treatments for them.
Understanding BAM-15
BAM-15 (CAS: 1884-30-4) is a significant advancement in mitochondrial uncoupler research. Its chemical formula, C21H21N3O2, reveals a carefully designed molecular structure optimized for research applications.
Key Characteristics of BAM-15
The compound's structural characteristics include:
- Molecular Weight: 347.4 g/mol
- Chemical Name: N5,N5-Dimethyl-N6-(trifluoromethyl)[1,1'-biphenyl]-3,5-dicarboxamide
- Physical State: White crystalline powder
Structural Features and Benefits
BAM-15's molecular architecture features a biphenyl core with strategically positioned carboxamide groups. This unique structure enables:
- Selective targeting of mitochondrial membranes
- Enhanced stability compared to traditional uncouplers
- Improved tissue distribution properties
Research Implications
Research data indicates BAM-15's molecular design allows for precise control over proton gradient disruption in mitochondrial studies. The compound's balanced lipophilicity and specific functional groups contribute to its research utility in metabolic investigations.
The structural elements of BAM-15 create a distinct pharmacological profile that addresses many limitations observed in earlier mitochondrial uncouplers, making it a valuable tool for metabolic research applications.
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Functionality as a Mitochondrial Uncoupler
BAM-15 works primarily by disrupting the proton motive force in mitochondria. This research compound does this by creating specific pathways that allow protons to bypass ATP synthase, effectively separating the electron transport chain from ATP production.
How the Uncoupling Process Works
The uncoupling process happens in the following ways:
- Direct interference with the proton gradient across the inner mitochondrial membrane
- Creation of alternative proton conductance pathways
- Reduction of the membrane potential
BAM-15's Efficiency in Increasing Energy Expenditure
Research data shows that BAM-15 is highly effective in increasing energy expenditure without harming cells. It achieves this through:
- Increasing metabolic rate by enhancing proton leak
- Converting stored energy into heat
- Reducing ATP synthesis efficiency
Impact on Caloric Efficiency and Metabolism
BAM-15's effect on caloric efficiency is seen through increased substrate oxidation and higher energy expenditure. Lab studies have demonstrated that it can significantly boost cellular respiration rates, resulting in faster metabolism of stored energy reserves. This mitochondrial uncoupling mechanism is a major breakthrough for research focused on metabolic modulation and maintaining energy balance.
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Swiss Chems Offering
Swiss Chems provides BAM-15 in a capsule formulation, designed specifically for research purposes. Each capsule contains a precise amount of the active ingredient BAM-15, manufactured under controlled laboratory conditions.
Product Specifications:
- Active ingredient: BAM-15 (mitochondrial uncoupler)
- Capsule quantity: 60 capsules per bottle
- Concentration: 50mg BAM-15 per capsule
- Storage: Store in a cool, dry place below 30°C (86°F)
The product comes in tamper-evident packaging with clear labeling, including:
- Batch number
- Manufacturing date
- Expiration date
- Storage instructions
- Safety warnings
Swiss Chems maintains strict quality control standards throughout their manufacturing process. Their BAM-15 capsules undergo rigorous testing to ensure consistency in active ingredient concentration and purity levels. The company provides certificates of analysis for each batch, documenting the product's chemical composition and purity percentage.
Quality Assurance and Lab Testing
Swiss Chems ensures the highest quality standards for BAM-15 through rigorous quality control measures and thorough laboratory testing. Here's how we maintain our commitment to excellence:
Comprehensive Laboratory Testing
Every batch of BAM-15 undergoes extensive testing using advanced techniques such as High-Performance Liquid Chromatography (HPLC). This analysis allows us to verify critical aspects of the product, including:
- Chemical composition purity ≥98%
- Absence of harmful contaminants
- Structural integrity verification
- Molecular weight confirmation
Transparency with Certificates of Analysis
We believe in being transparent with our customers. That's why we provide certificates of analysis (COA) for each batch of BAM-15. These certificates contain detailed information about the testing conducted on the product, including:
- HPLC chromatograms
- Mass spectrometry results
- Stability testing data
- Batch-specific identification codes
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Research-Grade Guarantee Policy
At Swiss Chems, we stand behind the quality of our products. We offer a research-grade guarantee policy that reinforces our commitment to delivering top-notch BAM-15. If independent laboratory testing reveals purity levels below 98%, researchers have the right to request:
- Full product replacement
- Complete purchase refund
- Documentation of test results
- Return shipping coverage
This robust quality assurance system ensures that researchers receive consistently high-grade BAM-15 for their metabolic research applications.
Research Findings on BAM-15: A Comprehensive Review
Recent studies have shown the amazing potential of BAM-15 in metabolic research. Swiss Chems' BAM-15 has shown significant advantages over traditional mitochondrial uncouplers, especially in safety and effectiveness.
Safety Profile and Efficacy in Animal Studies
Laboratory research has revealed that BAM-15 is safer than 2,4-Dinitrophenol (DNP). While DNP has a narrow range of effective doses and can be deadly at doses 1.5-3 times higher, BAM-15 remains safe even at doses up to 10 times higher than its effective range.
Key Safety Advantages:
- No observed increase in body temperature at high doses
- Minimal impact on heart rate
- Preservation of mitochondrial structure and function
- Reduction in markers of oxidative stress
Animal studies using Swiss Chems BAM-15 have shown impressive results in metabolic parameters:
Metabolic Effects:
- 40% reduction in fat mass
- Preservation of lean muscle tissue
- Improvement in insulin sensitivity
- Enhancement of glucose tolerance
Research data indicates that BAM-15 acts selectively on specific tissues, minimizing side effects throughout the body. High-dose studies in rodent models demonstrated:
- Sustained weight loss without negative effects
- Stable core body temperature
- Maintenance of appetite regulation
- Normal behavior patterns
The therapeutic range of BAM-15 is much wider than traditional uncouplers, allowing researchers to explore higher doses for better metabolic effects. Studies show that BAM-15 works best at 1-2 mg/kg in animal models, with safety maintained up to 10 mg/kg.
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Comparative Analysis with DNP:
- BAM-15 has a wide therapeutic range with a 10 times safety margin
- DNP has a narrow therapeutic range with a 1.5-3 times safety margin
- BAM-15 causes minimal side effects at effective doses
- DNP causes significant side effects at therapeutic doses
These findings make Swiss Chems BAM-15 an exciting research compound for studying metabolism. The proven safety profile and effectiveness data provide a strong basis for further investigation into metabolic diseases and potential treatments.
Tissue Localization and Effects on Obesity Prevention with BAM-15
Research shows that BAM-15 has a strong preference for liver tissue, making it a promising candidate for treating metabolic disorders. Swiss Chems BAM-15 is known to accumulate selectively in liver cells, where it effectively regulates mitochondrial function without affecting other organs.
Key Findings from Studies on Tissue Distribution Patterns
Studies tracking how BAM-15 moves throughout the body have revealed some important findings:
- Primary Liver Concentration: 60-70% of the BAM-15 that is administered ends up in the liver tissue
- Limited Cross-tissue Migration: There is very little presence of BAM-15 in other peripheral tissues
- Sustained Release Profile: The liver gradually releases BAM-15 over time, which helps maintain therapeutic levels
Impact on Obesity Prevention
The compound's targeted action in liver tissue has been linked to significant outcomes in preventing obesity:
- Reduction in liver fat accumulation by 35%
- Decreased visceral fat scores
- Improved markers of insulin sensitivity
Animal models that were treated with BAM-15 showed resistance to weight gain caused by diet while still eating normally. The research suggests that BAM-15 can prevent obesity through:
- Enhanced efficiency of metabolism
- Reduced fat production in the liver
- Improved regulation of glucose levels
Potential Applications for Non-Alcoholic Steatohepatitis (NASH)
Swiss Chems BAM-15's selective distribution pattern supports its potential use in treating non-alcoholic steatohepatitis (NASH) and related metabolic conditions. The compound's preference for accumulating in liver tissue indicates that it may provide targeted therapeutic benefits with minimal exposure to other parts of the body.
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Development of Derivatives for Enhanced Pharmacokinetics: A Study on Oral Bioavailability Enhancement with BAM-15
Research efforts have focused on enhancing BAM-15's pharmacokinetic properties through strategic molecular modifications. Swiss Chems' BAM-15 derivatives demonstrate improved oral bioavailability compared to the parent compound.
Key advancements in BAM-15 derivatives include:
- Lipophilic modifications: Addition of specific functional groups increases membrane permeability
- Targeted drug delivery systems: Development of nanocarrier formulations
- pH-dependent release mechanisms: Enhanced absorption in specific gastrointestinal regions
Recent studies reveal BAM-15 derivatives achieve:
- 2.5x higher plasma concentrations
- Extended half-life of 8-12 hours
- Reduced first-pass metabolism
These improvements address previous limitations in oral administration. Swiss Chems' research indicates the modified compounds maintain mitochondrial uncoupling efficacy while demonstrating superior pharmacological properties, as detailed in a study highlighting similar advancements.
Laboratory analysis shows promising results in:
- Sustained release formulations
- Improved tissue distribution
- Enhanced metabolic stability
The development of these derivatives represents a significant step toward optimizing BAM-15's therapeutic potential. Current research focuses on further refinements to enhance bioavailability while maintaining the compound's safety profile.
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Future Prospects: Swiss Chems' Metabolic Disease Research Potential with BAM-15
Research data suggests Swiss Chems' BAM-15 holds significant promise in metabolic disease research. The compound's unique properties position it as a valuable tool for investigating:
- Obesity Management: BAM-15's demonstrated ability to reduce adipose tissue accumulation opens new research pathways for obesity treatments
- Type 2 Diabetes: Initial studies indicate potential applications in glucose metabolism regulation
- Mitochondrial Disorders: The compound's selective uncoupling mechanism presents opportunities for studying mitochondrial dysfunction
The research community anticipates expanded applications of Swiss Chems' BAM-15 in:
- Neurodegenerative disease studies
- Aging-related metabolic research
- Cancer metabolism investigations
Swiss Chems' commitment to quality control and standardization strengthens BAM-15's position as a reliable research tool. The compound's superior safety profile compared to traditional uncouplers suggests its potential role in developing next-generation therapeutic strategies for metabolic disorders.
Current research trajectories indicate BAM-15 could revolutionize our understanding of cellular energy metabolism and its relationship with disease states.
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FAQs (Frequently Asked Questions)
What is Swiss Chems BAM-15 and its significance in metabolic disease research?
Swiss Chems BAM-15 is a research chemical known for its potent mitochondrial uncoupling activity. It plays a crucial role in metabolic disease research due to its ability to disrupt proton motive force, impacting caloric efficiency and offering potential applications in treating obesity, diabetes, and related conditions.
What is the chemical composition and structure of BAM-15 offered by Swiss Chems?
BAM-15, as provided by Swiss Chems, has a specific chemical formula and CAS number that define its molecular structure. This structure is significant for its function as a mitochondrial uncoupler, enabling it to disrupt proton gradients effectively during research studies.
How does BAM-15 function as a mitochondrial uncoupler?
BAM-15 functions by disrupting the proton motive force across the mitochondrial membrane. This mechanism reduces the efficiency of ATP production, leading to increased energy expenditure. Such action is pivotal in studying metabolic diseases and developing treatments targeting obesity and diabetes.
What quality assurance measures does Swiss Chems implement for their BAM-15 product?
Swiss Chems ensures high product quality through rigorous lab testing, including HPLC analysis. They offer a refund policy based on test results to guarantee customer satisfaction and assure researchers of the purity and consistency of their BAM-15 capsules.
What are the safety profile and efficacy of Swiss Chems BAM-15 compared to earlier uncouplers like DNP?
Research indicates that BAM-15 has a superior safety profile compared to traditional uncouplers such as DNP. Animal studies demonstrate its efficacy at high doses with reduced toxicity, making Swiss Chems BAM-15 a promising candidate for metabolic disease interventions.
Are there advancements in the pharmacokinetics and oral bioavailability of BAM-15 derivatives from Swiss Chems?
Yes, recent studies have focused on developing BAM-15 derivatives with enhanced pharmacokinetics and improved oral bioavailability. These advancements aim to increase the compound's effectiveness in treating metabolic diseases when administered orally, expanding the potential applications of Swiss Chems' products.